Asymmetric C2−C3 Cyclopentannulation of the Indole Ring
Journal of the American Chemical Society2009Vol. 131(6), pp. 2096–2097
Citations Over TimeTop 10% of 2009 papers
Abstract
Chiral nonracemic alkynyl(alkoxy)carbene complexes of tungsten(0) undergo the [3 + 2] cyclization toward alpha-methylindoles and 1,6-dimethyl-1,2,3,4-tetrahydropyridine to provide 2,3-indoline-fused cyclopentenone and 2,3-piperidine-fused cyclopentenone skeletons, respectively, with very high enantiomeric purities (96-99% ee).
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