Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles
Journal of the American Chemical Society2009Vol. 131(16), pp. 5728–5729
Citations Over TimeTop 1% of 2009 papers
Abstract
An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.
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