Chiral Brønsted Acid-Catalyzed Enantioselective Three-Component Povarov Reaction
Journal of the American Chemical Society2009Vol. 131(13), pp. 4598–4599
Citations Over TimeTop 1% of 2009 papers
Abstract
The three-component Povarov reaction of aldehydes (2), anilines (3), and benzyl N-vinylcarbamate 4 in the presence of 0.1 equiv of chiral phosphoric acid 5 afforded cis-2,4-disubstituted tetrahydroquinolines (1) in good yields and excellent enantiomeric excesses. The shortest synthesis of torcetrapib reported to date, which features this key three-component reaction, is documented.
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