IBiox[(−)-menthyl]: A Sterically Demanding Chiral NHC Ligand
Journal of the American Chemical Society2009Vol. 131(24), pp. 8344–8345
Citations Over TimeTop 1% of 2009 papers
Abstract
An exceedingly sterically demanding, rigid, and chiral NHC ligand, IBiox[(-)-menthyl] (1), was prepared and structurally characterized. With a buried volume of approximately 50%, this ligand arguably represents one of the most sterically demanding monodentate ligands. The ability to use aryl chloride substrates in intramolecular palladium-catalyzed alpha-arylations reveals its unique reactivity. Moreover, C(2)-symmetric 1 allows the highly enantioselective formation of oxindoles with up to 99% ee.
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