Total Synthesis of (−)-Acutumine
Journal of the American Chemical Society2009Vol. 131(19), pp. 6674–6675
Citations Over TimeTop 10% of 2009 papers
Abstract
The first total synthesis of the tetracyclic alkaloid (-)-acutumine is described. Key reactions include an asymmetric ketone allylation mediated by Nakamura's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, and the Lewis acid-promoted cyclization of an amine onto an alpha,beta-unsaturated dimethyl ketal.
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