Cation-Triggered Drug Release from a Porous Zinc−Adeninate Metal−Organic Framework
Journal of the American Chemical Society2009Vol. 131(24), pp. 8376–8377
Citations Over TimeTop 1% of 2009 papers
Abstract
A porous anionic metal-organic framework, bio-MOF-1, constructed using adenine as a biomolecular building block is described. The porosity of this material is evaluated, its stability in biological buffers is studied, and its potential as a material for controlled drug release is investigated. Specifically, procainamide HCl is loaded into the pores of bio-MOF-1 using a simple cation exchange process. Exogenous cations from biological buffers are shown to affect the release of the adsorbed drug molecules.
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