Enantioselective Hydrogenation of N−H Imines
Journal of the American Chemical Society2009Vol. 131(29), pp. 9882–9883
Citations Over TimeTop 10% of 2009 papers
Guohua Hou, Francis Gosselin, Wei Li, J. Christopher McWilliams, Yongkui Sun, Mark Weisel, Paul O’Shea, Cheng‐yi Chen, Ian W. Davies, Xumu Zhang
Abstract
N-H ketoimines 3a-3v are readily prepared in high yield via organometallic addition to nitriles and isolated as corresponding bench-stable hydrochloride salts. Homogeneous asymmetric hydrogenation of unprotected N-H ketoimines 3a-3v using Ir-(S,S)-f-binaphane as catalyst provides chiral amines 4a-4v in 90-95% yield with enantioselectivities up to 95% ee.
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