Triazole−Au(I) Complexes: A New Class of Catalysts with Improved Thermal Stability and Reactivity for Intermolecular Alkyne Hydroamination
Journal of the American Chemical Society2009Vol. 131(34), pp. 12100–12102
Citations Over TimeTop 10% of 2009 papers
Abstract
A series of 1,2,3-triazole-bound cationic Au(I) catalysts have been synthesized, and their structures have been characterized by X-ray crystallography. Variable-temperature NMR studies revealed dynamic triazole-Au cation coordination in solution. Reaction profiles clearly indicated that these new catalysts possess much better thermal stability than literature-reported Au catalysts, including IPrAu x NTf(2). By application of these catalysts, challenging intermolecular hydroaminations were achieved with less-reactive internal alkynes and unprotected aliphatic amines, giving excellent yields with low catalyst loading.
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