Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis
Journal of the American Chemical Society2009Vol. 131(31), pp. 10875–10877
Citations Over TimeTop 1% of 2009 papers
Abstract
The first enantioselective, organocatalytic alpha-trifluoromethylation and alpha-perfluoroalkylation of aldehydes have been accomplished using a readily available iridium photocatalyst and a chiral imidazolidinone catalyst. A range of alpha-trifluoromethyl and alpha-perfluoroalkyl aldehydes were obtained from commercially available perfluoroalkyl halides with high efficiency and enantioselectivity. The resulting alpha-trifluoromethyl aldehydes were subsequently shown to be versatile precursors for the construction of a variety of enantioenriched trifluoromethylated building blocks.
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