FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition
Citations Over TimeTop 10% of 2009 papers
Abstract
Chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) show the controlled release of Fe in low pH solution. The released Fe catalyzes H(2)O(2) decomposition into reactive oxygen species within cells, causing fast oxidation and deterioration of cellular membranes. Functionalized with luteinizing hormone-releasing hormone (LHRH) peptide via phospholipid, the fcc-FePt NPs can bind preferentially to the human ovarian cancer cell line (A2780) that overexpresses LHRH receptors and exhibit high toxicity to these tumor cells. In contrast, the fcc-FePt NPs pre-etched in the low pH (4.8) buffer solution show nonappreciable cytotoxicity. The work demonstrates that fcc-FePt NPs may function as a new type of agent for controlled cancer therapy.
Related Papers
- → Amyloid β cytotoxicity is enhanced or reduced depending on formation of amyloid β oligomeric forms(2020)8 cited
- Cytotoxicity test of medical device with silver nanoparticles(2010)
- → Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon(1980)77 cited
- Protective effect of Cynomorii Herba extract on $H_2O_2$-induced cytotoxicity(2004)
- Synthesis and antitumor activity of aza-chalcones and their Pt(IV) complexes(2011)