A Turn-On Fluorescent Sensor for Detecting Nickel in Living Cells
Journal of the American Chemical Society2009Vol. 131(50), pp. 18020–18021
Citations Over TimeTop 10% of 2009 papers
Abstract
We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni(2+) in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni(2+) over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni(2+) levels in a respiratory cell model.
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