Direct Alkenylation and Alkylation of Pyridone Derivatives by Ni/AlMe3 Catalysis
Journal of the American Chemical Society2009Vol. 131(44), pp. 15996–15997
Citations Over TimeTop 10% of 2009 papers
Abstract
Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe(3) catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).
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