On the Binding of Cationic, Water-Soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic Interactions
Journal of the American Chemical Society2010Vol. 132(4), pp. 1252–1254
Citations Over TimeTop 10% of 2010 papers
Fan Xia, Xiaolei Zuo, Renqiang Yang, Yi Xiao, Di Kang, Alexis Vallée‐Bélisle, Xiong Gong, Alan J. Heeger, Kevin W. Plaxco
Abstract
Water-soluble, cationic conjugated polymer binds single-stranded DNA with higher affinity than it binds double-stranded or otherwise "folded" DNA. This stronger binding results from the greater hydrophobicity of single-stranded DNA. Upon reducing the strength of the hydrophobic interactions, the electrostatic attraction becomes the important interaction that regulates the binding between the water-soluble conjugated polymer and DNA. The different affinities between the cationic conjugated polymer and various forms of DNA (molecular beacons and its open state; single-stranded DNA and double-stranded DNA and single-stranded DNA and complex DNA folds) can be used to design a variety of biosensors.
Related Papers
- → Interactions between adsorbents and adsorbates in aqueous solutions(2020)33 cited
- → The relationship of interaction forces in the protein adsorption onto polymeric microspheres(1999)107 cited
- → The interaction between hemoglobin and two surfactants with different charges(2007)59 cited
- → Control of the poly(N-isopropylacrylamide) phase transition via a single strand–double strand transformation of conjugated DNA(2013)20 cited
- → Electrostatic and hydrophobic interaction cooperative nanochaperone regulates protein folding(2023)14 cited