DNA Methylation Increases Nucleosome Compaction and Rigidity
Journal of the American Chemical Society2010Vol. 132(6), pp. 1782–1783
Citations Over TimeTop 10% of 2010 papers
Abstract
Cytosine methylation on CpG dinucleotides is an essential epigenetic modification in eukaryotes. How DNA methylation modulates nucleosome structure and dynamics has been a long-standing question. We implemented a single-molecule method to monitor the effects of DNA methylation on the structure and dynamics of mononucleosomes. Our studies show that DNA methylation induces a more compact and rigid nucleosome structure, providing a physical basis for how DNA methylation might contribute to regulating chromatin structure.
Related Papers
- → Electrostatic Mechanism of Nucleosome Spacing(1995)126 cited
- → Prediction of Nucleosome Positioning Based on Transcription Factor Binding Sites(2010)10 cited
- → The Effect of Nucleosome Phasing Sequences and DNA Topology on Nucleosome Spacing(1996)48 cited
- → Predicting Nucleosome Positions in Yeast: Using the Absolute Frequency(2012)5 cited
- → Compartmap enables inference of higher-order chromatin structure in individual cells from scRNA-seq and scATAC-seq(2021)1 cited