Callipeltoside A: A Cytotoxic Aminodeoxy Sugar-Containing Macrolide of a New Type from the Marine Lithistida Sponge Callipelta sp.

Citations Over TimeTop 11% of 1996 papers

Abstract

A cytotoxic glycoside macrolide, callipeltoside A, has been isolated from the marine lithistid sponge Callipelta sp., collected off New Caledonia. Structural assigment was accomplished through extensive 2D NMR spectroscopy. The complete relative stereochemistry is proposed from the analysis of ROESY and NOE difference experiments. Callipeltoside A (1) represents the first member of a new class of marine-derived macrolides, containing unusual structural features including a 4-amino-4,6-dideoxy-2-O,3-C-dimethyl-α-talopyranosyl-3,4-urethane unit.

Related Papers

• → Triterpene glycosides from Antarctic sea cucumbers III. Structures of liouvillosides A₄and A₅, two minor disulphated tetraosides containing 3-O-methylquinovose as terminal monosaccharide units from the sea cucumberStaurocucumis liouvillei(Vaney)(2011)47 cited
• → Amino Acid Derivatives from the Marine Sponge Jaspis digonoxea(1994)72 cited
• → Strychnobaillonine, an Unsymmetrical Bisindole Alkaloid with an Unprecedented Skeleton fromStrychnos icajaRoots(2014)29 cited
• → Additional cytotoxic substances isolated from the sponge-derived Gymnascella dankaliensis(2013)27 cited
• → Cespihypotins Q−V, Verticillene Diterpenoids from Cespitularia hypotentaculata(2008)22 cited