A Catalytic Enantioselective Synthesis of the Endothelin Receptor Antagonists SB-209670 and SB-217242. A Base-Catalyzed Stereospecific Formal 1,3-Hydrogen Transfer of a Chiral 3-Arylindenol

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Abstract

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Catalytic Enantioselective Synthesis of the Endothelin Receptor Antagonists SB-209670 and SB-217242. A Base-Catalyzed Stereospecific Formal 1,3-Hydrogen Transfer of a Chiral 3-ArylindenolWilliam M. Clark, Ann M. Tickner-Eldridge, G. Kris Huang, Lendon N. Pridgen, Mark A. Olsen, Robert J. Mills, Ivan Lantos, and Neil H. BaineView Author Information Synthetic Chemistry Department SmithKline Beecham Pharmaceuticals 709 Swedeland Road, P.O. Box 1539 King of Prussia, Pennsylvania 19406 Cite this: J. Am. Chem. Soc. 1998, 120, 18, 4550–4551Publication Date (Web):April 23, 1998Publication History Received12 November 1997Published online23 April 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/ja973882jhttps://doi.org/10.1021/ja973882jrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1622Altmetric-Citations116LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Genetics,Hydrogen,Rearrangement,Redox reactions Get e-Alerts

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