A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold: Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors

Citations Over TimeTop 17% of 1999 papers

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold: Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based InhibitorsRongze Kuang, Jeffrey B. Epp, Sumei Ruan, Hongyi Yu, Peng Huang, Shu He, Juan Tu, Norman M. Schechter, Jane Turbov, Christopher J. Froelich, and William C. GroutasView Author Information Department of Chemistry, Wichita State University, Wichita, Kansas 67260, Department of Dermatology & Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, and Department of Medicine, Northwestern University Medical School, Evanston, IL 60201 Cite this: J. Am. Chem. Soc. 1999, 121, 35, 8128–8129Publication Date (Web):August 21, 1999Publication History Received19 January 1999Published online21 August 1999Published inissue 1 September 1999https://pubs.acs.org/doi/10.1021/ja990160ehttps://doi.org/10.1021/ja990160erapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views768Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical specificity,Inhibitors,Monomers,Peptides and proteins,Scaffolds Get e-Alerts

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