Titanocene-Catalyzed Asymmetric Ketone Hydrosilylation: The Effect of Catalyst Activation Protocol and Additives on the Reaction Rate and Enantioselectivity
Journal of the American Chemical Society1999Vol. 121(24), pp. 5640–5644
Citations Over TimeTop 10% of 1999 papers
Abstract
The efficient asymmetric hydrosilylation of ketones with a chiral titanocene catalyst has been realized. In this procedure, (R,R)-ethylenebis(tetrahydroindenyl) titanium difluoride (1) was used as the precatalyst, and alcohol additives were employed. Aromatic and α,β-unsaturated ketones were reduced to the corresponding alcohols with a high level of enantioselectivity.
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