Uridine-Conjugated Ferrocene DNA Oligonucleotides: Unexpected Cyclization Reaction of the Uridine Base
Journal of the American Chemical Society2000Vol. 122(28), pp. 6767–6768
Citations Over TimeTop 11% of 2000 papers
Changjun Yu, Handy Yowanto, Yanjian Wan, Thomas J. Meade, Yoochul Chong, Michael J. Strong, Leslee H. Donilon, Jon Faiz Kayyem, Michael Gozin, Gary F. Blackburn
Abstract
The study of energy and electron-transfer processes through DNA duplexes and the development of DNA hybridization probes and electrochemical sensors have resulted in the incorporation of numerous transition-metal complexes into DNA oliognucleotides. These include ruthenium, osmium, iron, rhodium, and copper complexes. Ferrocene (Fc) and its derivatives are attractive electrochemical probes because of their stability and convenient synthetic chemistry. Fc-containing DNA oligonucleotides have been prepared by attaching ferrocenyl moieties to the 5‘ termini through either solid-phase synthesis using phosphoramidites or by reacting suitable ferrocenyl derivatives with end-functionalized oligonucleotides.
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