Total Synthesis of Enlicitide Decanoate
Journal of the American Chemical Society2025Vol. 147(13), pp. 11036–11048
Citations Over TimeTop 1% of 2025 papers
Hongming Li, David A. Thaisrivongs, Gao Shang, Qinghao Chen, Qinghao Chen, Lushi Tan, Kai‐Jiong Xiao, Reed T. Larson, Jeffrey T. Kuethe, Joshua E.-Y. Lee, Nicholas R. Deprez, Andrew Nolting, Marc Poirier, Paul G. Bulger, Erik L. Regalado, Mirlinda Biba, Fuh-Rong Tsay, Jimmy DaSilva, Chris K. Prier, Christopher A. Strulson, Kerstin Zawatzky, Zhu Liu, Justin A. Newman, Kathleen P. Sokolowsky, Weijuan Tang, Kari Hullen, Nimisha Thakur, Cody Welch, Smit Patel, Yu He, Jing Xu, Narayan Variankaval, Artis Klapars, Jongrock Kong, Richard Desmond, Richard J. Varsolona, Peter E. Maligres, Carlos A. Pons Siepermann, Lee Robison, Tiffany Piou, Clara Hartmanshenn, Anagha Chandra, Anisha Patel, M. Becker, Guiquan Liu, Duan Jian-jun, Baoqiang Wan, Chengqian Xiao, Yongpeng Yuan, Xiaohui Cao, Chen Lü, Ruxia Yi, Zhenhua Wu, Meiqing Feng, Donghong Li, Zhiyan Song, Yawei Dong, Jian‐Sheng Sun, Biao Li, Guangxin Shao, Louis‐Charles Campeau, Jingjun Yin
Abstract
We report the total synthesis of enlicitide decanoate, an orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9 that is being developed for the treatment of atherosclerotic cardiovascular disease. It is a highly complex macrocyclic peptide with a significant number of nonpeptide structural elements that presents a daunting synthetic chemistry challenge. We describe the development of a convergent, efficient, and robust manufacturing process that enables the large-scale production of enlicitide.
Related Papers
- Susquehanna Chorale Spring Concert "Roots and Wings"(2017)
- → DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION(2018)
- Коммуникaтивно- прaгмaтический aнaлиз дипломaтических бумaг (нa основе вербaльных нот)(2018)
- → ФОРМИРОВAНИЕ ГОТОВНОСТИ БУДУЩИХ ПЕДAГОГОВ К ОРГAНИЗAЦИИ РAБОТЫ ПО РAЗВИТИЮ ВAЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ ШКОЛЬНИКОВ(2023)