Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines
Journal of the American Chemical Society2018Vol. 140(23), pp. 7083–7087
Citations Over TimeTop 10% of 2018 papers
Abstract
Here we report highly efficient and chemoselective azadiene-imine reductive couplings catalyzed by (Ph-BPE)Cu-H that afford anti-1,2-diamines. In all cases, reactions take place with either aldimine or ketimine electrophiles to deliver a single diastereomer of product in >95:5 er. The products' diamines are easily differentiable, facilitating downstream synthesis.
Related Papers
- → Recent developments in enantioselective iron-catalyzed transformations(2019)58 cited
- → Allylstannane Allylation of Aldimines Activated by Chlorotrimethylsilane(1995)39 cited
- → Synthesis ofN-(Dimethylsulfamoyl)aldimines, a New Type of Aldimine Derivative(1997)14 cited
- → Chiral B(III) Lewis Acids(2000)19 cited
- → ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ(2024)