Isolation and Identification of Novel Tocotrienols from Rice Bran with Hypocholesterolemic, Antioxidant, and Antitumor Properties
Citations Over TimeTop 14% of 2000 papers
Abstract
Two novel tocotrienols were isolated from stabilized and heated rice bran, apart from the known alpha-, beta-, gamma-, and delta-tocopherols and tocotrienols. These new tocotrienols were separated by HPLC, using a normal phase silica column. Their structures were determined by ultraviolet, infrared, nuclear magnetic resonance, circular dichroism, and high-resolution mass spectroscopies and established as desmethyl tocotrienol [3, 4-dihydro-2-methyl-2-(4,8,12-trimethyltrideca-3'(E),7'(E), 11'-trienyl)-2H-1-benzopyran-6-ol] and didesmethy tocotrienol [3, 4-dihydro-2-(4,8,12-trimethyltrideca-3'(E),7'(E), 11'-trienyl)-2H-1-benzopyran-6-ol]. These tocotrienols significantly lowered serum total and LDL cholesterol levels and inhibited HMG-CoA reductase activity in chickens. They had much greater in vitro antioxidant activities and greater suppression of B16 melanoma cell proliferation than alpha-tocopherol and known tocotrienols. Results indicated that the number and position of methyl substituents in tocotrienols affect their hypocholesterolemic, antioxidant, and antitumor properties.
Related Papers
- → Influence of bran layer on rice milling quality(2023)3 cited
- → STUDIES OF RICE-BRAN THERAPY FOR CALCIUM UROLITHIASIS WITH IDIOPATHIC HYPERCALCIURIA(1984)3 cited
- Research and Application on Deep Processing Products of Rice Bran(2013)
- → STUDIES OF RICE-BRAN THERAPY FOR CALCIUM UROLOTHIASIS WITH IDIOPATHIC HYPERCALCIURIA(1984)
- In vitro effects of three wheat bran-derived fibres -wheat bran, ultrafine milled bran and soluble wheat bran fibre (AXOS)- on the gut microbiome(2014)