New Glycosides from Capsicum annuum L. Var. acuminatum. Isolation, Structure Determination, and Biological Activity
Citations Over Time
Abstract
Investigation of polar extracts from ripe fruits of Capsicum annuum L. var. acuminatum yielded three new glycosides, capsosides A (1) and B (2) and capsianoside VII (3), along with seven known compounds (4-10). The chemical structures were elucidated mainly by extensive nuclear magnetic resonance methods and mass spectrometry, and the biological activities of icariside E(5) (4) were tested by different assays. Icariside E(5), in contrast to capsaicin, neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. Interestingly, this compound protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal. These results suggest that icariside E(5) may have antioxidant properties that strengthen the importance of peppers in the Mediterranean diet.
Related Papers
- → Changes in the Surface Expression of Intercellular Adhesion Molecule 3, the Induction of Apoptosis, and the Inhibition of Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4 Cells Exposed to a Random Positioning Machine(2020)18 cited
- 시판 라면스프 및 고추가루 중의 매운맛 성분 Capsaicin 함량측정을 통해 추정된 한국인의 Capsaicin 섭취량 범위(1999)
- → [Oridonin inhibits proliferation of Jurkat cells via the down-regulation of Brg1].(2017)1 cited
- [MEKK2 regulates the production of interleukin 2].(2005)
- Effect of Programmed Death Ligand-1 signal on activity and apoptosis of Jurkat cell.(2010)