Zingerone as an Antioxidant against Peroxynitrite
Citations Over TimeTop 13% of 2005 papers
Abstract
Peroxynitrite (ONOO(-)), formed from the reaction of superoxide ((*)O(2)(-)) and nitric oxide ((*)NO), induces cellular and tissue injury, resulting in several human diseases such as stroke, Alzheimer's disease, and atherosclerosis. Due to the lack of endogenous enzymes responsible for ONOO(-) scavenging activity, finding a specific ONOO(-) scavenger is of considerable importance. In this study we examined the scavenging effects of zingerone from ginger against ONOO(-), intracellular RS (reactive species), and ONOO(-). The data show that zingerone can efficiently scavenge native ONOO(-) as well as ONOO(-) derived from the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1). Zingerone inhibited the formation of ONOO(-)-mediated tyrosine nitration through electron donation, nitration of bovine serum albumin (BSA) by ONOO(-), and intracellular RS and ONOO(-). The present study suggests that zingerone has an efficient ONOO(-) scavenging ability, which may be a potent ONOO(-) scavenger for the protection of the cellular defense activity against ONOO(-)- involved diseases.
Related Papers
- A GEOMETRIC MEAN IN THE FURUTA INEQUALITY(2002)
- Susquehanna Chorale Spring Concert "Roots and Wings"(2017)
- Коммуникaтивно- прaгмaтический aнaлиз дипломaтических бумaг (нa основе вербaльных нот)(2018)
- → ФОРМИРОВAНИЕ ГОТОВНОСТИ БУДУЩИХ ПЕДAГОГОВ К ОРГAНИЗAЦИИ РAБОТЫ ПО РAЗВИТИЮ ВAЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ ШКОЛЬНИКОВ(2023)