Syntheses and Biological Activities of Octahydro-1H-cyclopenta[d]pyrimidine Derivatives
Journal of Agricultural and Food Chemistry2006Vol. 55(1), pp. 143–147
Citations Over TimeTop 24% of 2006 papers
Abstract
Various nitromethylene derivatives were synthesized regioselectively. Compounds 8a-f were obtained by the reaction of 1-((5-chloropyridin-2-yl)methyl)-2-(nitromethylene)-octahydro-1H-cyclopenta[d]-pyrimidine (3) with primary amines and formaldehyde. The synthesized compounds were identified by 1H NMR, HRMS (EI), and IR, and preliminary bioassays indicated that most of them showed moderate insecticidal activities against Aphis craccivora. The relationship between hydrophobicity and biological activity was also discussed.
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