Protective Effect of Structurally Diverse Grape Procyanidin Fractions against UV-Induced Cell Damage and Death
Citations Over TimeTop 10% of 2011 papers
Abstract
UV radiation leads to the generation of reactive oxygen species (ROS). These molecules exert a variety of harmful effects by altering key cellular functions and may result in cell death. Several studies have demonstrated that human skin can be protected against UV radiation by using plant-derived antioxidants. Here we evaluated the in vitro capacity of several antioxidant polyphenolic fractions from grape, which differ in their degree of polymerization and percentage of galloylation, to protect HaCaT human keratinocytes against UV-induced oxidative damage. These fractions inhibited both basal and UVB- or UVA-induced intracellular ROS generation in this cell line. Consequently, the same fractions inhibited p38 and JNK1/2 activation induced by UVB or UVA radiation. The highest protective effect was for fractions rich in procyanidin oligomers and gallate esters. These encouraging in vitro results support further research and should be taken into consideration into the clinical pharmacology of plant-derived polyphenolic extracts as novel agents for skin photoprotection.
Related Papers
- → Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers(2014)143 cited
- → Photoprotective characteristics of natural antioxidant polyphenols(2014)137 cited
- → Q-TOF LC/MS identification and UHPLC-Online ABTS antioxidant activity guided mapping of barley polyphenols(2018)48 cited
- The Experimental Study of Yeouigeumhwang-san on Antioxidant Effects(2007)
- → Antioxidant activity and photoprotection of Mediterranean plants extracts(2017)