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Plant Antitumor Agents. 31.1 The Calycopterones, a New Class of Biflavonoids with Novel Cytotoxicity in a Diverse Panel of Human Tumor Cell Lines
Journal of Medicinal Chemistry1994Vol. 37(10), pp. 1465–1470
Citations Over TimeTop 22% of 1994 papers
Monroe E. Wall, M C Wani, Fekadu Fullas, J. B. OSWALD, Daniel M. Brown, Thawatchai Santisuk, V. Reutrakul, Andrew T. McPhail, Norman R. Farnsworth
Abstract
Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.
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