Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase
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ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDesign and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil ElastaseKazuyuki Ohmoto, Tetsuya Yamamoto, Toshihide Horiuchi, Hirotoshi Imanishi, Yoshihiko Odagaki, Kazuhito Kawabata, Tomohiko Sekioka, Yasushi Hirota, Shozo Matsuoka, Hisao Nakai, Masaaki Toda, John C. Cheronis, Lyle W. Spruce, Albert Gyorkos, and Maciej WieczorekView Author Information Ono Pharmaceutical Company, Ltd., Shimamoto, Mishima, Osaka 618-8585, Japan Medical and Pharmaceutical Services, Source Precision Medicine, Boulder, Colorado 80301 Discovery Chemistry, MAXIA Pharmaceuticals, Inc., San Diego, California 92121 Array Biopharma, Boulder, Colorado 80301 Gonex, Inc., Colorado State University, ARBL, Ft. Collins, Colorado 80523-1683 Cite this: J. Med. Chem. 2000, 43, 26, 4927–4929Publication Date (Web):November 30, 2000Publication History Received18 September 2000Published online30 November 2000Published inissue 1 December 2000https://pubs.acs.org/doi/10.1021/jm0004087https://doi.org/10.1021/jm0004087rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views601Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Inhibitors,Modification,Noncovalent interactions,Peptides and proteins,Substituents Get e-Alerts
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