0 citations
Nonsteroidal antiinflammatroy agents. 2. Synthesis of 4',5-disubstituted 3-diphenylylacetic acids and their derivatives with antiinflammatory and analgesic activities
Journal of Medicinal Chemistry1981Vol. 24(1), pp. 43–47
Citations Over Time
Yasumitsu Tamura, Yoshihiko Yoshimoto, Katsutoshi Kunimoto, Shinichi Tada, Shingo Matsumura, Masao Murayama, Yoshihisa Shibata, Hiroshi Enomoto
Abstract
A series of 5',5-disubstituted 3-biphenylylacetic acids (5a-n) and several alpha-methyl derivatives (5o-v) were prepared as analogues of a newly developed nonsteroidal antiinflammatory agent, 5'-chloro-5-methoxy-3-biphenylylacetic acid [1 (DKA-9), R = 4-C1Ph; R' = Me], and evaluated for antiinflammatory and analgesic activities using both carrageenan rat paw edema and AcOH writhing assays. Among them, 5-fluoro-3-biphenylylacetic acid (5m) showed the highest antiinflammatory activity, while 2-(3-biphenylyl)propionic acid (5o) showed the highest analgesic activity. However, they were less potent than 1 (R = 4-C1Ph; R' = Me) in these assays.
Related Papers
- → EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES(2014)7 cited
- → Synthesis of long chain lipid amides and their analgesic properties(2018)2 cited
- → Analgesic Effect of Several Nonsteroidal Anti-Inflammatory Drug Nanoaerosols(2016)1 cited
- → Nonsteroidal Anti-inflammatory Drugs(2014)1 cited
- → Analgesic effect of nonacidic nonsteroidal anti-inflammatory drugs.(1985)