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Tetrahydro-2-benzoxepins: a novel family of hypotensives

Journal of Medicinal Chemistry1981Vol. 24(1), pp. 64–67

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Ruth E. TenBrink, John M. McCall, Donald T. Pals, Robert B. McCall, John Orley, Steve J. Humphrey, Michael G. Wendling

Abstract

A novel series of 1-(alkylamino)-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins shows hypotensive activity. A typical example is 1-[2-(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)ethyl]-4-(4-fluorophenyl)piperazine. This compound is an alpha blocker with peripheral and central activities.

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