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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 1. Hydrazines
Journal of Medicinal Chemistry1986Vol. 29(11), pp. 2273–2280
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Christopher B. Chapleo, Malcolm Myers, Peter L. Myers, John F. Saville, Alan C. B. Smith, Michael R. Stillings, I.F. Tulloch, D.S. Walter, Anthony P. Welbourn
Abstract
The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamazepine.
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