Polyamine analogs with antitumor activity

Citations Over TimeTop 23% of 1990 papers

Abstract

A series of tetraamines derived from 1,8-diaminooctane was prepared and tested as antitumor agents. The reaction of 1,8-diaminooctane with acrylonitrile gave N,N'-bis(cyanoethyl)-1,8-diaminooctane, which was reduced to tetraamine 20. Alkylation of the terminal nitrogen atoms of the tetra-Boc derivative of this compound by methyl or ethyl halide followed by removal of the Boc groups gave the bis(alkyl)polyamines 26a and 26b, respectively. These three compounds exhibit promising antitumor activity in the mouse L1210 leukemia model. Coadministration of a polyamine oxidase inhibitor potentiated the antitumor activity.

Related Papers

• → Do Altmetrics Work? Twitter and Ten Other Social Web Services(2013)898 cited
• → An Introduction to Altmetrics(2014)115 cited
• → Using Altmetrics to Support Research Evaluation(2018)16 cited
• From attention to citation: What are altmetrics and how do they work?(2014)
• Susquehanna Chorale Spring Concert "Roots and Wings"(2017)