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2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as nonacidic antiinflammatory agents
Journal of Medicinal Chemistry1978Vol. 21(11), pp. 1158–1162
Citations Over TimeTop 21% of 1978 papers
Robert L. Clark, Arsenio A. Pessolano, B. E. Witzel, Thomas J. Lanza, T. Y. Shen, C. Gordon Van Arman, Edwin A. Risley
Abstract
Some 2-(substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines have good antiinflammatory and analgesic activity. A few possess activity comparable to phenylbutazone or indomethacin without producing the irritation in the gastrointestinal tract that acidic antiinflammatory compounds cause.
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