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Resolution and absolute configuration of an ergoline-related dopamine agonist, trans-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H(or 2H)-pyrazolo[3,4-g]quinoline
Journal of Medicinal Chemistry1983Vol. 26(8), pp. 1112–1116
Citations Over TimeTop 1% of 1983 papers
Robert D. Titus, Edmund C. Kornfeld, Noel D. Jones, James A. Clemens, E. Barry Smalstig, Ray W. Fuller, R Hahn, Martin D. Hynes, Norman R. Mason
Abstract
The title compound (+/-)-5 (R = Pro) (LY141865) has been resolved into a (-) isomer and a (+) isomer as the D- and L-tartrate salts, respectively. Biological studies have shown that dopamine agonist activity is a property of only the (-) isomer. Crystallographic analysis has proven that the absolute configuration of the active (-) isomer is the same as that of the natural ergolines.
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