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Steroidogenesis inhibitors. 1. Adrenal inhibitory and interceptive activity of trilostane and related compounds
Journal of Medicinal Chemistry1984Vol. 27(7), pp. 928–931
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Rokbert G. Christiansen, Helmut Neumann, U. Joseph Salvador, Malcolm R. Bell, H. Philip Schane, John E. Creange, G. O. Potts, Anthony J. Anzalone
Abstract
Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory activity.
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