Bacteriopurpurinimides: Highly Stable and Potent Photosensitizers for Photodynamic Therapy
Journal of Medicinal Chemistry2001Vol. 45(2), pp. 255–258
Citations Over TimeTop 11% of 2001 papers
Yihui Chen, Andrew E. Graham, William R. Potter, Janet Morgan, Lurine A. Vaughan, David A. Bellnier, Barbara W. Henderson, Allan R. Oseroff, Thomas J. Dougherty, Ravindra K. Pandey
Abstract
The in situ conversion of the unstable bacteriochlorophyll a present in Rhodobacter sphaeroides produced highly stable bacteriopurpurin-18 which in a sequence of reactions was converted into a series of alkyl ether analogues of bacteriopurpurin-18-N-alkylimides with long wavelength absorption near 800 nm. The effective photosensitizers were found to localize in mitochondria but did not show any specific displacement of (3)H-PK11195, suggesting that the mitochondrial peripheral benzodiazepine receptor is not the cellular binding site for this class of compounds.
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