Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 1. Discovery and Optimization of Salicylaldehyde Thiosemicarbazone Thrombopoietin Mimics
Journal of Medicinal Chemistry2002Vol. 45(17), pp. 3573–3575
Citations Over Time
Kevin J. Duffy, Anthony N. Shaw, Evelyne Delorme, Susan B. Dillon, Connie L. Erickson‐Miller, Leslie Giampa, Yifang Huang, Richard M. Keenan, Peter Lamb, Nannan Liu, Stephen G. Miller, Alan T. Price, Jon Rosen, Heather Smith, Kenneth J. Wiggall, Lihua Zhang, Juan I. Luengo
Abstract
High-throughput screening has resulted in the discovery of thiosemicarbazone thrombopoietin mimics. A shared pharmacophore hypothesis between this series and a previously identified class, the pyrazol-4-ylidenehydrazines, led to the rapid optimization of both potency and efficacy of the thiosemicarbazones. The application of high-throughput chemistry and purification techniques allowed for the rapid elucidation of structure-activity relationships.
Related Papers
- → Synthesis, structural characterization and biological activity of helicin thiosemicarbazone monohydrate and a copper(II) complex of salicylaldehyde thiosemicarbazone(1999)192 cited
- → Synthesis, characterization and physicochemical properties of copper(II) complexes containing salicylaldehyde semicarbazone(2003)68 cited
- Synthesis and biological activities of fluoreneazo - salicylaldehyde thiosemicarbazone derivatives.(2009)
- Synthesis of Fluorenetriazo-Salicylaldehyde Thiosemicarbazone Derivatives and Their Activities to Plant Growth(2010)
- → Magnetic properties of copper(II) mixed ligand complex with thiophene-2-aldehyde thiosemicarbazone and salicylaldehyde semicarbazone(2017)