SAR by MS: A Ligand Based Technique for Drug Lead Discovery Against Structured RNA Targets
Journal of Medicinal Chemistry2002Vol. 45(18), pp. 3816–3819
Citations Over TimeTop 10% of 2002 papers
Eric E. Swayze, Elizabeth A. Jefferson, Kristin A. Sannes‐Lowery, Lawrence B. Blyn, Lisa M. Risen, Satoshi Arakawa, Stephen A. Osgood, Steven A. Hofstadler, Richard H. Griffey
Abstract
A technique for lead discovery vs RNA targets utilizing mass spectrometry (MS) screening methods is described. The structure-activity relationships (SAR) derived from assaying weak binding motifs allows the pharmacophores discovered to be elaborated via "SAR by MS" to higher affinity ligands. Application of this strategy to a subdomain of the 23S rRNA afforded a new class of compounds with functional activity.
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