Discovery of Tyrosine-Based Potent and Selective Melanocortin-1 Receptor Small-Molecule Agonists with Anti-inflammatory Properties
Journal of Medicinal Chemistry2003Vol. 46(7), pp. 1123–1126
Citations Over TimeTop 10% of 2003 papers
Timothy F. Herpin, Guixue Yu, Kenneth E. Carlson, George Morton, Ximao Wu, Liya Kang, Huji Tuerdi, Ashish Khanna, John S. Tokarski, R. Michael Lawrence, John E. Macor
Abstract
The melanocortin-1 receptor (MC-1R) is a G-protein-coupled receptor involved in inflammation and skin pigmentation. Compound 2 is the first highly potent and selective MC-1R small-molecule agonist reported. Compound 2 showed efficacy in an acute model of inflammation, which has demonstrated the role of MC-1R in modulation of inflammation.
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