Anticancer and Antimalarial Efficacy and Safety of Artemisinin-Derived Trioxane Dimers in Rodents
Journal of Medicinal Chemistry2004Vol. 47(5), pp. 1299–1301
Citations Over TimeTop 10% of 2004 papers
Gary H. Posner, Andrew J. McRiner, Ik‐Hyeon Paik, Surojit Sur, Kristina Borstnik, Suji Xie, Theresa A. Shapiro, Adebusola A. Alagbala, Barbara A. Foster
Abstract
In only four chemical steps from naturally occurring artemisinin (1), trioxane dimers 6 and 7 were prepared on a multigram scale in overall 32-44% yields. In mice, both isonicotinate N-oxide dimer 6 and isobutyric acid dimer 7 were considerably more antimalarially efficacious than clinically used sodium artesunate (2) via both oral and intravenous administration. In the transgenic adenocarcinoma of mouse prostate model, some of the trioxane dimers had potent anticancer activity.
Related Papers
- → Enhancing the antimalarial activity of artesunate(2020)70 cited
- → Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients(1996)120 cited
- → Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009(2010)38 cited
- → Preparation of a Novel Monoclonal Antibody against the Antimalarial Drugs, Artemisinin and Artesunate(2007)20 cited
- Efficacy and effectiveness of five day treatment of uncomplicated falciparum with artemisinin or artesunate in Vietnam.(1999)