Synthesis, Biological Activity, and Quantitative Structure−Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives
Journal of Medicinal Chemistry2004Vol. 47(9), pp. 2236–2242
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Miguel F. Braña, Ana Gradillas, Ángel M. Gómez, Nuria Acero, F. Llinares, Dolores Muñoz‐Mingarro, Cristina Abradelo, Fernanda Rey-Stolle, Mercedes Yuste, Joaquín M. Campos Rosa, Miguel Á. Gallo, Antonio Espinosa
Abstract
A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.
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