Neoclerodane Diterpenes as a Novel Scaffold for μ Opioid Receptor Ligands
Journal of Medicinal Chemistry2005Vol. 48(15), pp. 4765–4771
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Wayne W. Harding, Kevin Tidgewell, Nathan Byrd, Howard Cobb, Christina M. Dersch, Eduardo R. Butelman, Richard B. Rothman, Thomas E. Prisinzano
Abstract
Structural modification of salvinorin A, the active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study a nonnitrogenous neoclerodane diterpene with mu opioid receptor affinity (13) that is an agonist at mu opioid receptors. This represents the identification of a novel structural class of mu opioid receptor agonists.
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