Synthesis and in Vitro Antileukemic Activity of Some New 1,3-(Oxytetraethylenoxy)cyclotriphosphazene Derivatives
Journal of Medicinal Chemistry2005Vol. 49(2), pp. 806–810
Citations Over TimeTop 23% of 2005 papers
Mariola Siwy, Danuta Sęk, Bożena Kaczmarczyk, Iwona Jaroszewicz, Anna Nasulewicz‐Goldeman, Marzena Pełczyńska, Dmitry Nevozhay, Adam Opolski
Abstract
A new series of 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives bearing 2-chloroethylamine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base (after condensation with 2-chloroethylamine) units and having also 2-naphthyl or anthraquinone groups as cosubstituents has been synthesized. The in vitro cytotoxic activity of these compounds against a panel of four cancer cell lines has been studied. Most of the compounds exhibited antiproliferative activity in the range of the international criterion for synthetic agents (4 microg/mL) against the MOLT4, L 1210, HL-60, and P388 cell lines chosen for testing.
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