Identification of 7-Phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a New Class of Src Kinase Inhibitors
Journal of Medicinal Chemistry2004Vol. 47(27), pp. 6666–6668
Citations Over TimeTop 19% of 2004 papers
Diane H. Boschelli, Biqi Wu, Ana Carolina Barrios Sosa, Haris Durutlic, Fei Ye, Yuri E. Raifeld, Jennifer M. Golas, Frank Boschelli
Abstract
We disclose here a new class of kinase inhibitors, obtained by replacing the phenyl ring of a 3-quinolinecarbonitrile system with a thiophene ring. When suitably substituted, the resultant 7-phenylaminothieno[3,2-b]pyridine-6-carbonitrile analogues show potent inhibition of Src kinase activity.
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