Rational Design of New Antituberculosis Agents: Receptor-Independent Four-Dimensional Quantitative Structure−Activity Relationship Analysis of a Set of Isoniazid Derivatives
Journal of Medicinal Chemistry2004Vol. 47(15), pp. 3755–3764
Citations Over TimeTop 10% of 2004 papers
Kerly Fernanda Mesquita Pasqualoto, Elizabeth Igne Ferreira, Osvaldo A. Santos‐Filho, A. J. Hopfinger
Abstract
A 4D-QSAR analysis was carried out for a set of 37 hydrazides whose minimum inhibitory concentrations against M. tuberculosis var. bovis were evaluated. These ligands are thought to act like isoniazid in mycolic acid biosynthesis. Results indicate that nonpolar groups in the acyl moiety of ligands markedly decrease biological activity. Molecular modifications of the ligand NAD moiety, including nonpolar groups and hydrogen bond donor and acceptor groups, seemingly improve ligand interactions with amino acid residues of the InhA active site.
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