Mechanisms of Cytotoxicity of Selected Organogold(III) Compounds
Journal of Medicinal Chemistry2005Vol. 48(21), pp. 6761–6765
Citations Over TimeTop 10% of 2005 papers
Marcella Coronnello, Enrico Mini, Barbara Caciagli, Maria Agostina Cinellu, Alberto Bindoli, Chiara Gabbiani, Luigi Messori
Abstract
The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.
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