Identification of Ellagic Acid as Potent Inhibitor of Protein Kinase CK2: A Successful Example of a Virtual Screening Application
Journal of Medicinal Chemistry2006Vol. 49(8), pp. 2363–2366
Citations Over TimeTop 10% of 2006 papers
Giorgio Cozza, Paolo Bonvini, Elisa Zorzi, Giorgia Poletto, Mario A. Pagano, Stefania Sarno, Arianna Donella‐Deana, Giuseppe Zagotto, Angelo Rosolen, Lorenzo A. Pinna, Flavio Meggio, Stefano Moro
Abstract
Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. Using a virtual screening approach, we have identified the ellagic acid, a naturally occurring tannic acid derivative, as a novel potent CK2 inhibitor. At present, ellagic acid represents the most potent known CK2 inhibitor (K(i) = 20 nM).
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