Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities
Journal of Medicinal Chemistry2006Vol. 49(9), pp. 2845–2849
Citations Over TimeTop 14% of 2006 papers
Christophe Biot, Wassim Daher, Natascha Leleu‐Chavain, Thierry Fandeur, Jamal Khalife, Daniel Dive, Erik De Clercq
Abstract
Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.
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