Synthesis, Stability, and Antimicrobial Studies of Electronically Tuned Silver Acetate N-Heterocyclic Carbenes
Journal of Medicinal Chemistry2008Vol. 51(6), pp. 1577–1583
Citations Over TimeTop 10% of 2008 papers
K.M. Hindi, T.J. Siciliano, Semih Durmus, Matthew J. Panzner, Doug Medvetz, D V S Reddy, L.A. Hogue, Christine E. Hovis, Julia K. Hilliard, R.J. Mallet, Claire A. Tessier, Carolyn L. Cannon, Wiley J. Youngs
Abstract
A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.
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