Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites
Citations Over TimeTop 10% of 2010 papers
Abstract
Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol: inhibition of tumor necrosis factor (TNF) alpha induced NFkappaB activity, cylcooxygenases (COX-1 and COX-2), aromatase, nitric oxide production in endotoxin-stimulated macrophages, proliferation of KB or MCF7 cells, induction of quinone reductase 1 (QR1), accumulation in the sub-G(1) phase of the cell cycle, and quenching of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. Two metabolites showed activity in these assays; the 3-sulfate exhibited QR1 induction, DPPH free radical scavenging, and COX-1 and COX-2 inhibitory activities and the 4'-sulfate inhibited NFkappaB induction, as well as COX-1 and COX-2 activities. Resveratrol and its 3'-sulfate and 4-sulfate inhibit NO production by NO scavenging and down-regulation of iNOS expression in RAW 264.7 cells. Resveratrol sulfates displayed low antiproliferative activity and negligible uptake in MCF7 cells.
Related Papers
- → Resveratrol and derivatives for the prevention and treatment of cancer(2010)246 cited
- → Resveratrol cytotoxicity is energy‐dependent(2019)23 cited
- Uptake of resveratrol and role of resveratrol-targeting protein, quinone reductase 2, in normally cultured human prostate cells(2009)
- → Resveratrol—The “Chateau Hormone” for Cardio Diabetic Protection(2014)1 cited
- → Resveratrol: Biochemistry and Functions(2009)2 cited